RESEARCH GROUP
Prof. Bernhard Kräutler

Research areas

B12 - the Organometallic Cofactor

Chlorophyll Breakdown

Functionalized Fullerenes and Porphyrins



 

B12 - the Organometallic Cofactor

Discovery, structure analysis, synthesis and biological chemistry of vitamin B12 and antivitamin B12 (applying electro-synthesis and supramolecular design; in cooperation with Austrian and foreign research teams).

B 12
Recent publications

Marissa B. Guzzo, Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel,
Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, Joseph L. Timpona, Soumya Gogula,
Michael R. Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W. Jacobsen, Guo-Fang Zhang,
Liem Nguyen
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs
PLOS Pathogens, DOI: 10.1371/journal.ppat.1005949

F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank, K. Gruber, K. Wurst, M. J. Warren,
B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin -
the Nonnatural Rhodium Homologue of Coenzyme B12

Angew. Chem. Int. Ed. 55, 11281-11289, (2016), DOI: 10.1002/anie.201603738

K. E. Helliwell, A. D. Lawrence, A. Holzer, U. J. Kudahl, S. Sasso, B. Kräutler, D. J. Scanlan,
M. J. Warren, A. G. Smith
Cyanobacteria and eukaryotic algae use different chemical variants of vitamin B12
Curr. Biol., 26, 999-1008 (2016)

B. Kräutler
Antivitamins B12 - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)

M. Hunger, E. Mutti, A. Rieder, B. Enders, E. Nexo, B. Kräutler
An Organometallic B12-DNA-Conjugate-Synthesis, Structure Analysis &
Studies of Binding to Human B12-Transporter Proteins

Chem. Eur. J., 20, 13103-13107 (2014)

M. Ruetz, R. Salchner, K. Wurst, S. Fedosov, B. Kräutler
Phenylethinylcobalamin: a Light-stable and Thermolysis-resistant Organometallic B12-Derivative
Prepared by Radical Synthesis

Angew. Chem. Int. Ed., 52, 11406-11409 (2013), Angew. Chem., 125, 11617-11620 (2013)

I. Kobylianski, F. Widner, B. Kräutler, P. Chen
Co-C bond energies in adenosylcobinamide and methylcobinamide in the gas phase and in silico
J. Amer. Chem. Soc., 135, 13648-13651 (2013)

E. Mutti, M. Ruetz, H. Birn, B. Kräutler, E. Nexo
4-Ethylphenyl-cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12
deficiency in mice

PLOS one, 8, e75312 (2013), open access

 

 

Chlorophyll Breakdown

Discovery, structure analysis, synthesis and biological chemistry in the area of chlorophyll breakdown
(using electrosynthesis and enzymology; in cooperation with Austrian and foreign research teams).

Chlorophyll Breakdown

Recent publications


Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber,
Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive,
Chiral Photoswitches

Angew. Chem. Int. Ed. 55, 15760-15765, (2016), DOI: 10.1002/anie.201609481

M. Scherl, T. Müller, C. R. Kreutz, R. G. Huber, E. Zass, K. R. Liedl, B. Kräutler
Chlorophyll Catabolites in Fall Leaves of the Wych Elm Tree Present a Novel Glycosylation Motif
Chem. Eur. J. 22, 9498-9503 (2016)

B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs
of Ripening, Senescence and Cell Death (Review)

Angew. Chem. Int. Ed., 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)

I. Süssenbacher, S. Hörtensteiner, B. Kräutler
A Dioxobililn-Type Fluorescent Chlorophyll Catabolite as a Transient Early Intermediate
of the Dioxobilin-Branch of Chlorophyll Breakdown in Arabidopsis thaliana

Angew. Chem. Int. Ed., 54, 13777-13781(2015), Angew. Chem., 127, 13981-13985 (2015),
open access

M. Roiser, T. Müller, B. Kräutler
Colorless Chlorophyll Catabolites in Senescent Florets of Broccoli (Brassica oleracea var. Italica)
J. Agric. Food Chem., 63, 1385-1392 (2015), open access

C. Vergeiner, M. Ulrich, C. Li, X. Liu, T. Müller, B. Kräutler
Stereo- and Regioselective Phyllobilane Oxidation in Leaf Homogenates of the Peace Lily
(Spathiphyllum wallisii) – Hypothetical Endogenous Path to Yellow Chlorophyll Catabolites

Chem. Eur. J., 21, 136-149 (2015), open access

C. Li, M. Ulrich, K. Wurst, T. Müller, B. Kräutler
Blue Transition Metal Complexes of a Natural Bilin-Type Chlorophyll Catabolite
Chem. Sci., 5, 3388-3395, (2014), open access

S. Moser, T. Müller, M.-O. Ebert, S. Jockusch, N. J. Turro, B. Kräutler
Blue Luminescence of Ripening Bananas
Angew. Chem. Int. Ed. 47, 8954-8957 (2008), Angew. Chem. 120, 9087-9091 (2008)

 

Functionalized Fullerenes and Porphyrins

Design, synthesis and structural investigations in solution and in the solid state (solid state chemistry, supramolecular design and crystal design; in cooperation with Austrian and foreign research teams).

Fullerenes

Recent publications


S. Banala, K. Wurst, B. Kräutler
Panchromatic π-Extended Porphyrins from Conjugation with Quinones
ChemPlusChem, 81, 477-488, (2016), DOI: 10.1002/cplu.201600115

S. Banala, R. Huber, T. Müller, M. Fechtel, K. Liedl, B. Kräutler
Porphyrin-LEGO: Synthesis of a Hexafullereno-Diporphyrin Using Porphyrins Programmed
for [4+2]-Cycloaddition

ChemmComm, 48, 4359-4361 (2012)

S. Banala, T. Rühl, K. Wurst, B. Kräutler
Blackening Porphyrins by Conjugating with Quinones
Angew. Chem. Int. Ed 48, 599-603 (2009), Angew. Chem. 121, 607-611 (2009)

A. Duarte-Ruiz, K. Wurst, B. Kräutler
The Orthogonal (e, e, e)-tris-Adduct of 9, 10-Dimethylanthracene with
C60-Fullerene - a hidden Corner Stone of Fullerene Chemistry

Helv. Chim. Acta 91, 1401-1408 (2008)

A. Rieder, B. Kräutler
Loading a Porphyrin with Fullerene-Units
J. Am. Chem. Soc. 122, 9050-9051 (2000)

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