2017


Synthesis and incorporation of 13C-labeled DNA building blocks to probe structural dynamics of DNA by NMR.

Nußbaumer F, Juen MA, Gasser C, Kremser J, Mueller T, Tollinger M, Kreutz C.*

Nucl. Acids Res. (2017); accepted. link


Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.
Vuorinen A, Engeli RT, Leugger S, Kreutz C, Schuster D, Odermatt A*, Matuszczak B.*
Bioorg Med Chem Lett. (2017);27(13):2982-2985.

RNA binding and chaperone activity of E. coli cold-shock protein CspA.
Rennella E, Sara T, Juen M, Wunderlich C, Imbert L, Solyom Z, Favier A, Ayala I, Weinhaeupl K, Schanda P, Konrat R, Kreutz C, Brutscher B.* 
Nucl. Acids Res. (2017);45(7):4255-4268. link

The synthesis of 15N7-Hoogsteen face-labeled adenosine amidite for solid phase RNA synthesis.
Neuner S, Kreutz C*, Micura R.*
Monatsh. Chem. (2017);148(1):149-155. link

A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J.*
Angew Chem Int Ed Engl. (2017);56(1):401-404. link

2016


Measurement of ligand-target residence times by 1H relaxation dispersion NMR spectroscopy.

Moschen T, Grutsch S, Juen, MA, Wunderlich CH, Kreutz C*, Tollinger M*.

J. Med. Chem. (2016);59(23):10788-10793. link

        

NMR resonance assignments for the tetramethylrhodamine binding RNA aptamer 3 in complex with the ligand 5-carboxy-tetramethylrhodamine.
Duchardt-Ferner E*, Juen M, Kreutz C, Wöhnert J.
Biomol NMR Assign. (2016);11(1):29-34. link

Excited states of nucleic acids probed by proton relaxation dispersion NMR spectroscopy.
Juen MA, Wunderlich CH, Nußbaumer F, Tollinger M, Kontaxis G, Konrat R, Hansen DF*,
Kreutz C.*
Angew. Chem. Int. Ed. Engl. (2016);55(39):12008-12012. link

m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.
Zhou H, Kimsey IJ, Nikolova EN, Sathyamoorthy B, Grazioli G, McSally J, Bai T, Wunderlich CH,
Kreutz C, Andricioaei I*, Al-Hashimi HM.*
Nat. Struct. Mol. Biol. (2016);23:803-810. link

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Ren A, Vusurovic N, Gebetsberger J, Gao P, Juen M,
Kreutz C, Micura R*, Patel DJ.*
Nat. Chem. Biol. (2016);12:702-708. link

Chlorophyll Catabolites in Fall Leaves of the Wych Elm Tree Present a Novel Glycosylation Motif.
Scherl M, Müller T,
Kreutz C, Huber RG, Zass E*, Liedl KR,* Kräutler B.*
Chemistry Eur. J. (2016);22(28):9498-9503. link

Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations.

Longhini AP, LeBlanc RM, Becette O, Salguero C, Wunderlich CH, Johnson BA, D’Souza VM, Kreutz C, Dayie TK.*

Nucleic Acids Research (2016);44(6):e52. link


2015


Stable Isotope-Labeled RNA Phosphoramidites to Facilitate Dynamics by NMR.
Wunderlich CH, Juen MA, LeBlanc RM, Longhini AP, Dayie TK,
Kreutz C.*
Methods Enzymol. 2015;565:461-494. link

A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.
Košutić M, Neuner S, Ren A, Flür S, Wunderlich C, Mairhofer E, Vušurović N, Seikowski J, Breuker K, Höbartner C, Patel DJ*,
Kreutz C*, Micura R.*
Angew. Chem. Int. Ed. Engl. (2015);127(50):15343-15348. link

NMR resonance assignments for the class II GTP binding RNA aptamer in complex with GTP.
Wolter AC, Duchardt-Ferner E, Nasiri AH, Hantke K, Wunderlich CH,
Kreutz C, Wöhnert J.*
Biomol NMR Assign. (2015);10(1):101-105. link

Hydroxymethylated Dioxobilins in Senescent Arabidopsis thaliana Leaves: Sign of a Puzzling Biosynthetic Intermezzo of Chlorophyll Breakdown.
Süssenbacher I,
Kreutz C, Christ B, Hörtensteiner S, Kräutler B.*
Chem. Eur. J. (2015), 21. link

The "speedy" synthesis of atom-specific 15N imino/amido-labeled RNA.

Neuner S, Santner T, Kreutz C, Micura R.*

Chem. Eur. J. (2015), 21(33):11634-11643. link


Expanding the Scope of 2'-SCF3 Modified RNA.
Jud L, Košutić M, Schwarz V, Hartl M,
Kreutz C, Bister K, Micura R.*
Chem. Eur. J. (2015);21(29):10400-7. link

Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.
Koch M, Flür S,
Kreutz C, Ennifar E, Micura R*, Polacek N.*
Proc. Natl. Acad. Sci. USA (2015);112(20):E2561-8. link

Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction.
Domingo O, Hellmuth I, Jäschke A,
Kreutz C, Helm M.*
Nucleic Acids Res. (2015); 43(11):5275-5283. link

Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1–RNA Binding.
Moschen T, Wunderlich C, Spitzer R, Levic J, Micura R, Tollinger M*,
Kreutz C.*
Angew. Chem. Int. Ed. (2015); 54(2):560-563. link

2014


Chemo-Enzymatic Synthesis of Selectively 13C/15N-Labeled RNA for NMR Structural and Dynamics Studies.
Alvarado LJ, Longhini AP, LeBlanc RM, Chen B,
Kreutz C, Dayie TK.*
Methods in Enzymology (2014); 549:133-162. link

Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.
Spenkuch F, Hinze G, Kellner S,
Kreutz C, Micura R, Basche T, Helm M.*
Nucleic Acids Res. (2014); 42(20):12735-12745. link

NMR resonance assignments of the archaeal ribosomal protein L7Ae in the apo form and bound to a 25 nt RNA.
Moschen T, Wunderlich C,
Kreutz C, Tollinger M.*
Biomol. NMR Assign. (2014);9:177. link


A gatekeeper helix determines substrate specificity of Sjögren Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

Keller M*, Zander U, Fuchs J, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner E, Marquez J.*

Nat. Comm. (2014); 5:4439. link


Magnetic resonance access to transiently formed protein complexes.

Sára T, Schwarz TC, Kurzbach D, Wunderlich C, Kreutz C, Konrat R.*

Chemistry Open (2014); 3(3):115-123. link


Regio-selective Chemical-Enzymatic Synthesis of Pyrimidine Nucleotides Facilitates RNA Structure and Dynamics Studies.

Alvarado LJ, LeBlanc RM, Longhini AP, Keane SC, Niyati J, Yildiz ZF, Tolbert BS, D’Souza VM, Summers MF,

Kreutz C, Dayie TK.*

ChemBioChem (2014); 15(11):1573-1577. link


Surprising base pairing and structural properties of 2'-Trifluoromethythio-Modified RNA.

Kosutic M, Jud L, Da Veiga C, Frener M, Fauster K, Kreutz C, Ennifar E*, Micura R.*

J. Am. Chem. Soc. (2014); 136(18):6656-6663. link


2013


A novel paramagnetic relaxation enhancement tag for nucleic acids: A tool to study structure and dynamics of RNA.
Wunderlich CH, Huber RG, Spitzer R, Liedl KR, Kloiber K, Kreutz C*
ACS Chem. Biol. (2013);8(12):2697-2706. link


Efficient fluorophores based on pyridyl-enolato and enamido difluoroboron complexes: Simple alternatives to boron-dipyrromethene (bodipy) dyes.

Graser M, Kopacka  H, Wurst K, Ruetz M, Kreutz C, Müller T, Hirtenlehner C, Monkowius U, Knoer G, Bildstein B.*  Inorganica Chimica Acta (2013); 405:116–120.


A personal perspective on chemistry driven RNA research.

Micura R*, Kreutz C*, Breuker K.*

Biopolymers (2013); 99(12):1114-1123. link


2012


2'-SCF3 Uridine-A Powerful Label for Probing Structure and Function of RNA by 19F-NMR Spectroscopy.

Fauster K, Kreutz C, Micura R.*

Angew. Chem. Int. Ed. Engl. (2012); 51(52):13080-13084.


Pseudoknot preorganization of the preQ1 class I riboswitch.

Santner T#, Rieder U#, Kreutz C*, Micura R.*

J. Am. Chem. Soc. (2012); 134(29):11928-11931. link

# these authors contributed equally


Synthesis of 6-13C-pyrimidine nucleotides as Spin-Labels for RNA dynamics.

Wunderlich CH, Spitzer R, Santner T, Fauster K, Tollinger M, Kreutz C*

  1. J.Am. Chem. Soc. (2012); 134(17):7558-7569. link


2011 & before


book contributions


NMR of Large Molecules

Wunderlich C, Grutsch S, Tollinger M, Kreutz C, (2014), in ‘Handbook of Chemical and Biological Plant Analytical Methods’, edited by Kurt Hostettmann, Shilin Chen, Andrew Marston and Hermann Stuppner. Chichester, UK: John Wiley & Sons, Ltd, pp 361-378.


Investigations on fluorine-labeled ribonucleic acids by 19F-NMR spectroscopy.

Kreutz C, Micura R.

Modified Nucleotides in Biochemistry, Biotechnology and Medicine (Editor: P. Herdewijn), Wiley-VCH, (2008), 3-22.


 
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