Assoz.Prof.Dr. Thomas Müller


Institute of Organic Chemistry, University of Innsbruck

Innrain 80/82, A-6020 Innsbruck, AUSTRIA


Tel.: +43-512-507-57720

Fax: +43-512-507-57799

e-mail: thomas.mueller@uibk.ac.at

 

Research Interests


Imaging Mass Spectrometry, Structure Elucidation using Mass Spectrometry.



Projects & Funding


Sparkling Science - Bundesministerium für Wirtschaft, Wissenschaft und Forschung


                                              INDIAN SUMMER IN TYROL

                                              Fall Colors in the Alpine Regions of Tyrol



Teaching


726302 Strukturaufklärung I (MS)

726410 Angewandte und Technische Organische Chemie

726851 Organische Spektroskopie für Fortgeschrittene I (MS)

726257 Praktikum Festphasensynthese & Naturstoffisolation & Nanochemie

726303 Organisch-chemisches Praktikum I

726350 Seminar Biologische Organische Chemie

 

Publications


2017


Kuprian, E., Munkler, C., Resnyak, A. Zimmermann, S., Tuong, T.D., Gierlinger, N., Müller, T., Livingston III, D.P., Neuner, G. Complex bud architecture and cell-specific chemical patterns enable supercooling of Picea abies bud primordia. DOI: 10.1111/pce.13078.


Nußbaumer F., Juen M.A., Gasser C., Kremser J., Mueller T., Tollinger M., Kreutz C. Synthesis and incorporation of 13C-labeled DNA building blocks to probe structural dynamics of DNA by NMR. Nucl. Acids Res. (2017); 45(15): 9178-9192.


Jochriem, M.,  Kirchler, C.G., Laus, G.,  Wurst, K., Kopacka, H., Müller T. and Schottenberger, H. Synthesis and crystal structures of non-symmetric 1,3-di(alkyloxy)imidazolium salts. Z. Naturforsch. 2017, 72b, 617-626.


Mittelberger, C., Yalcinkaya, H., Pichler, C., Gasser, J., Scherzer, G., Erhart, T., Schumacher, S., Holzner, B., Janik, K., Robatscher, P., Müller, T., Kräutler, B., Oberhuber, M. Pathogen-Induced Leaf Chlorosis: Products of Chlorophyll Breakdown Found in Degreened Leaves of Phytoplasma-Infected Apple (Malus × domestica Borkh.) and Apricot (Prunus armeniaca L.) Trees Relate to the Pheophorbide a Oxygenase/Phyllobilin Pathway. Journal of Agricultural and Food Chemistry 65/13, S. 2651 - 2660.



2016


Vanicek, St., Kopacka, H., Wurst, K., Müller, T., Hassenrück, C., Winter, R.F., Bildstein, B. Monofunctionalized Cobaltocenium Compounds by Dediazoniation Reactions of Cobaltoceniumdiazonium Bis(hexafluorophosphate). Organometallics 2016, 35, 2101−2109


Scherl, M., Müller, T., Kreutz, C.R., Huber, R.G., Zass, E., Liedl, K.R., Kräutler, B. Chlorophyll Catabolites in Fall Leaves of the Wych Elm Tree Present aNovel Glycosylation Motif. Chem. Eur.J. 2016, 22,9498 –9503.



2015


Vergeiner, C., Ulrich, M., Li, C., Liu, X., Müller, T., Kräutler, B. Stereo- and Regioselective Phyllobilane Oxidation in Leaf Homogenates of the Peace Lily (Spathiphyllum wallisii) – Hypothetical Endogenous Path to Yellow Chlorophyll Catabolites. Chem. Eur. J. 2015, 21, 136-149.


Roiser, M., Müller, T., Kräutler, B. Colorless Chlorophyll Catabolites in Senescent Florets of Broccoli (Brassica oleracea var. Italica). J. Agric. Food Chem. 2015, 63, 1385-1392.


Müller, T., Kräutler, B. Leuchtende Bananen – Chlorophyll-Abbau in Blättern und Früchten. Praxis der Naturwissenschaften – Chemie in der Schule 2015, 1/64, 28-33.


Prock, J.; Strabler, C.; Viertl, W.; Kopacka, H.; Obendorf, D.; Müller, T.; Tordin, E.; Salzl, S.; Knör, G.; Mauro, M.; De Cola, L.; Brüggeller, P. Unusual stability of dyads during photochemical hydrogen production. Dalton Transactions 2015, 44, 20936 - 20948.


2014


Bain, R.M.; Pulliam, C.J.; Yan, X.; Moore, K.F.; Müller, T.; Cooks, R.G. Mass Spectrometry in Organic Synthesis: Claisen–Schmidt Base-Catalyzed Condensation and Hammett Correlation of Substituent Effects. Journal Of Chemical Education 2014, 91 (11), 1985–1989.


Keller, M. A.; Zander, U.; Fuchs, J. E.; Kreutz, C.; Watschinger, K.; Müller, T.; Golderer, G.; Liedl, K. R.; Ralser, M.; Kräutler, B.; Werner, E. R.; Marquez, J. A. A Gatekeeper Helix Determines the Substrate Specificity of Sjögren-Larsson Syndrome Enzyme Fatty Aldehyde Dehydrogenase. Nature Communications 2014, 5, Art. Nr. 4439.


Li, C.; Ulrich, U.; Wurst, K.; Müller, T.; Kräutler, B. Blue Transition Metal Complexes of a Natural Bilin- Type Chlorophyll Catabolite. Chemical Science 2014, 5, 3388 - 3395.


Müller, T.; Vergeiner, S.; Kräutler, B. Structure Elucidation of Chlorophyll Catabolites (Phyllobilins) by ESI-Mass Spectrometry – Pseudo-molecular Ions and Fragmentation Analysis of a Nonfluorescent Chlorophyll Catabolite (NCC). International Journal of Mass Spectrometry 2014, 365-366, 48 - 55.


Vergeiner, S.; Schafferer, L.; Haas, H.; Müller, T. Improved MALDI-TOF Microbial Mass Spectrometry Imaging by Application of a Dispersed Solid Matrix. Journal Of The American Society For Mass Spectrometry 2014, 25, 8, 1498 - 1501.


Pittracher, M.; Frisch, U.; Kopacka, H.; Wurst, K.; Müller, T.; Oehninger, L.; Ott, I.; Wuttke, E.; Scheerer, S.; Winter, R. F.; Bildstein, B. π-Complexes of Tropolone and Its N-Derivatives: Ambidentate [O,O]/[N,O]/[N,N]-Cycloheptatrienyl Pentamethylcyclopentadienyl Ruthenium Sandwich Complexes. Organometallics 2014, 33, 7, 1630 - 1643.


Vanicek, S.; Kopacka, H.; Wurst, K.; Müller, T.; Schottenberger, H.; Bildstein, B. (2014): Chemoselective, Practical Synthesis of Cobaltocenium Carboxylic Acid Hexafluorophosphate. Organometallics 2014,  33, 5, 1152 - 1156.



2013


Christ, B., Süssenbacher, I., Moser, S., Bichsel, N., Müller, T., Kräutler, B., Hörtensteiner, S. Cytochrome P450 CYP89A9 Is Involved in the Formation of Major Chlorophyll Catabolites during Leaf Senescence in Arabidopsis. The Plant Cell 2013, 25, 5, 1868-1880.


Graser, M., Kopacka, H., Wurst, K., Ruetz, M., Kreutz, C., Müller, T., Hirtenlehner, C., Monkowius, U., Knör, G., Bildstein B. Efficient fluorophores based on pyridyl-enolato and enamido difluoroboron complexes: Simple alternatives to boron-dipyrromethene (bodipy) dyes. Inorganica Chimica Acta 2013, 405, 116–120.


Cooks, R.G., Müller, Th. Through a Glass Darkly: Glimpses into the Future of Mass Spectrometry. Advances in Mass Spectrometry 2013, 2, Special Issue, S0001.


Graser, M., Kopacka, H., Wurst, K., Müller, T., Bildstein, B. Structurally diverse pyridyl or quinolyl enolato/enamido metal complexes of Li, Zr, Fe, Co, Ni, Cu and Zn. Inorganica Chimica Acta 2013, 401, 38–49.


Scherl, M.; Müller, T. Über das Verschwinden des Chlorophylls,Teil 2 / Schülerexperimente rund um die Blattfarbstoffe. Chemie & Schule 2013, 3, 17 - 21.


Müller, T.; Scherl, M.; Kräutler, B. Über das Verschwinden des Chlorophylls, Teil 1 / Die Herbstverfärbung und blau leutende Bananen. Chemie & Schule 2013, 28, 9 - 12.


2012


Müller, Th., Badu-Tawiah, A., Cooks, R.G. Accelerated Carbon-Carbon Bond-Forming Reactions in Preparative Electrospray. Angewandte Chemie International Edition 2012, 51, 47, 11832-11835.


Moser, S., Müller, Th., Holzinger, A., Lütz, C., Kräutler, B. Structures of Chlorophyll Catabolites in Bananas (Musa acuminata) lay out a Split Path of Chlorophyll Breakdown in a Ripening Fruit Chem. Eur. J., 18, 10873-10885 (2012).


Scherl, M., Müller, Th., Kräutler, B. Chlorophyll Catabolites in Senescent Leaves of the Lime Tree (Tilia cordata). Chemistry & Biodiversity 2012, 9, 11, 2605-2617.


Banala, S., Huber, R.G., Müller, T., Fechtel, M., Liedl, K.R., Kräutler, B. Porphyrin-LEGO®: Synthesis of a Hexafullereno-Diporphyrin Using Porphyrins Programmed for [4+2]-Cycloaddition. Chemical Communications 2012, ChemmComm, 48, 4359-4361 (2012).


Christ, B., Schelbert, S., Aubry, S., Süssenbacher, I., Müller, T., Kräutler, B., Hörtensteiner, S. MES16, a Member of the Methyl Esterase Protein Family, Specifically Demethylates Fluorescent Chlorophyll Catabolites During Chlorophyll Breakdown in Arabidopsis. Plant Physiology 2012, 158, S. 628 - 641.


2011


Müller, T., Rafelsberger, M., Vergeiner, C., Kräutler, B. A Dioxobilane as Product of a Divergent Path of Chlorophyll Breakdown in Norway Maple. Angew. Chemie Int. Ed. 2011, DOI: 10.1002/anie.201106336.


Müller, T., Oradu, S., Demian R.I., Cooks, R.G., Kräutler, B. Direct Plant Tissue Analysis and Imprint Imaging by Desorption Electrospray Ionization Mass Spectrometry. Analytical Chemistry 2011, DOI: 10.1021/ac201123t.


Eisenstecken,D., Enk, B., Kopacka, H., Wurst, K., Müller, T., Pevny, F., Winter, R.F., Bildstein, B. Redox-Responsive Rhodocenium [O,O]-, [N,O]-, [N,N]-, and [N,C,N]-Metalloligands. Eur. J. Inorg. Chem. 2011, 19, 2958–2966.


Eller, S., Trettenbrein, B., Fessler, M., Haringer, S., Ruggenthaler, M., Gutmann, R., Van der Veer, W.E., Kopacka, H., Müller, T., Obendorf, D., Brügeller, P. Surprising photochemical reactivity and visible light-driven energy transfer in heterodimetallic complexes. Dalton Transactions 2011, 40, S. 3815 - 3829.


Ulrich, M., Moser, S., Müller, T., Kräutler, B. How the Colourless ‘Nonfluorescent’ Chlorophyll Catabolites Rust. Chemistry - A European Journal 2011, 17, 8, S. 2330–2334.


Müller, T., Kräutler, B. Chlorophyll Breakdown as Seen in Bananas: Sign of Aging and Ripening – A Mini-Review. Gerontology 2011. In press (DOI: 10.1159/000321877)

2010


Kräutler, B., Banala, S., Moser, S., Vergeiner, C., Müller, T., Lütz, C., Holzinger, A. A novel blue fluorescent chlorophyll catabolite accumulates in senescent leaves of the peace lily and indicates a split path of chlorophyll breakdown. FEBS Letters 2010, 584/19, S. 4215 - 4221.


Banala, S., Moser, S., Müller, T., Kreutz, C., Holzinger, A., Lütz, C., Kräutler, B. Hypermodified fluorescent chlorophyll catabolites - Source of blue luminescence in senescent leaves. Angew. Chemie Int. Ed. 2010, 49/30, S. 5174 - 5177.


Enk, B., Eisenstecken, D., Kopacka, H., Wurst, K., Müller, T., Penvy, F., Winter, R. F., Bildstein, B. Doubly N-Functionalized Pentafulvenes and Redox-Responsive [N,N]- and [N,C,N]-Pincer Bis(imidoyl)pentamethylruthenocene Metalloligands. Organometallics 2010, 29, S. 3169 - 3178.


2009


Moser, S., Müller, T., Holzinger, A., Luetz, C., Jockusch, S., Turro, N.J., Kräutler, B. Fluorescent Chlorophyll Catabolites in Bananas Light up Blue Halos of Cell Death. Proc. Natl. Acad. Sci. 2009, 106, 37, 15538-15543.


Moser, S., Müller, T., Oberhuber, M., Kräutler, B. Chlorophyll Catabolites - Chemical and Structural Foorprints of a Fascinating Biological Phenomenon. Europ. J. Org. Chem. 2009, 1, 21-31.


Enk, B., Kopacka, H., Wurst, K., Müller, T., Bildstein, B. An Efficient, Modular Route to New 2-Acyl-6-aminopentafulvenes and Planar-Chiral [N,O]-Functionalized Pentamethylruthenocenes 2009. Organometallics 28/18, S. 5575 - 5586.


Fessler, M., Eller, S., Bachmann, C., Gutmann, R., Trettenbrein, B., Kopacka, H., Müller, T., Brügeller, P. Regio- and chemoselective oxidation of the bis(bidentate) phosphine cis,trans,cis-1,2,3,4-tetrakis(diphenylphosphino)cyclobutane via cobalt(II) mediated dioxygen activation. Dalton Transactions 2009, S. 1383 - 1395.


2008


Moser, S., Ulrich, M., Müller, T., Kräutler, B. A yellow chlorophyll catabolite is a pigment of the fall colours. Photochem. Photobiol. Sci. 2008, 7(12), 1577-1581.


Moser, S., Müller, T., Ebert, M.O., Jockusch, S., Turro, N.J., Kräutler, B. Blue Luminescence of Ripening Bananas. Angew. Chem. Int. Ed. 2008, 47, 8954-8957.


Hörtensteiner, S.; Müller, T.; Kräutler, B. (2008): The Mechanism of Chlorophyll Degradation in Plants (Highlight). Chimia 2008, 62/5, S. 440 - 440.


Kräutler, B., Müller, T. Nature's Fruitful Chemistry (Instant Insight) Chem. Biol. 3, B79 (2008).


2007


Müller, T.,Ulrich, M., Ongania K.-H., Kräutler B. Colorless Tetrapyrrolic Chlorophyll Catabolites Found in Ripening Fruit Are Effective Antioxidants. Angew. Chem. Int. Ed. 2007, 46, 8699-8702.


Pruzinska, A., Anders, I., Aubry, S., Schenk, N., Tapernoux-Luethi, E., Mueller, T., Kraeutler, B., Hoertensteiner, S. In vivo participation of red chlorophyll catabolite reductase in chlorophyll breakdown. Plant Cell 2007, 19(1), 369-387.


Gutmann, R., Eller, S., Fessler, M., van der Veer, W. E., Dumfort, A., Kopacka, H., Müller, T., Brüggeller, P. Switching on the photochemical reactivity in heterodimetallic OsII-RuII bipyridyl complexes containing a bis(bidentate) phosphine. Inorganic Chemistry Communications 2007, 10/12, S. 1510 - 1514.


Zidorn, C., Spitaler, R., Grass, S., Mader, J., Mueller, T., Ellmerer, E.P., Stuppner, H. Four new hypocretenolides (guaian-12,5-olides) from Leontodon rosani (Astereaceae, Chichorieae). Biochemical Systematics and Ecology 2007, 35/5, S. 301 - 307.


2006


Berghold, J., Müller, T., Ulrich, M., Hörtensteiner, S., Kräutler, B. Chlorophyll breakdown in Maize: On the Structure of Two Nonfluorescent Chlorophyll Catabolites. Monatshefte fuer Chemie 2006, 137(6), 751-763.


Müller, T., Moser, S., Ongania, K.H., Pruzinska, A., Hörtensteiner, S., Kräutler, B. A divergent path of chlorophyll breakdown in the model plant Arabidopsis thaliana. ChemBioChem 2006, 7(1), 40-42.


Berghold, J., Müller, T., Ulrich, M., Hörtensteiner, S., Kräutler, B. Chlorophyll Breakdown in Maize: On the Structure of Two Nonfluorescent Chlorophyll Catabolites Chemical Monthly 137, 751-763 (2006).


Sinnecker, P., Müller, T., Kräutler, B., Lanfer-Marquez, U.M. Search for Chlorophyll Catabolites in Maturing Soybean Seeds. In "Pigments in Food – A Challenge to Life Sciences" R. Carle, A. Schieber, F. C. Stinitzing (Eds.) Shaker Verlag, Aachen, p. 289-291 (2006).


2005


Pruzinska, A., Tanner, G., Aubry, S., Anders, I., Moser, S., Müller, T., Ongania, K.H., Kräutler, B., Youn, J.Y., Lijegren, S.J., Hörtensteiner, S. Chlorophyll breakdown in senescent Arabidopsis leaves. Characterization of chlorophyll catabolites and of chlorophyll catabolic enzymes involved in the degreening reaction. Plant Physiology 2005, 139(1), 52-63.


1997-2004


Müller, T., Posch, U. C., Lindner, H. Separation of phenylthiohydantoin amino acids by capillary electrochromatography. Electrophoresis 2004, 25(4-5):578-85.


Kräutler, B., Müller, T., Duarte-Ruiz, A. Efficient preparation of monoadducts of [60]fullerene and anthracenes by solution chemistry and their thermolytic decomposition in the solid state. Chemistry-A European Journal 2001, 7, 3223-35.


Duarte-Ruiz, A., Müller, T., Wurst, K., Kräutler, B. The bis-adducts of the [5,6]-fullerene C-60 and anthracene. Tetrahedron 2001, 57, 3709-14.


Schwenninger, R., Müller, T., Kräutler, B. Concise Route to Symmetric Multiadducts of [60]Fullerene: Preparation of an Equatorial Tetraadduct by Orthogonal Transposition. Journal of the American Chemical Society 1997, 119, 9317-9318.


Kräutler, B., Müller, T., Maynollo, J., Gruber, K., Kratky, C., Ochsenbein, P., Schwarzenbach, D., Bürgi, H. B. A Topochemically Controlled, Regiospecific Fullerene Bisfunctionalization. Angewandte Chemie - International Edition in English 1996, 35, 1204-1206.



Talks


Thomas Müller, Simone Moser, Markus Ulrich, Srinivas Banala, Bernhard Kräutler.: Chlorophyll Breakdown in Higher Plants: Unexpected Diversity of Catabolites. 9th International Conference on Tetrapyrrole Photoreceptors in Photosynthetic Organisms (ICTPPO 2009), Asilomar Conference Center, Monterey, CA, USA,  26.-31. Juli 2009



Covers


 
               
              
              
              

T.Müller/R.G.Cooks                   B.Kräutler/T. Müller                 B.Kräutler/T. Müller                 B.Kräutler/T. Müller

  Inside Cover 2012                          Cover 2011                             Cover 2011                         Inside Cover 2010

                                

             
          
              
  

  B.Kräutler/T. Müller                    B.Kräutler/T. Müller               B.Kräutler/T. Müller                B.Kräutler/H.B. Bürgi 

      Cover 2009                                 Cover 2008                             Cover 2007                               Cover 1996

 
 
Diese Seiten werden auf einem Server der Universitaet Innsbruck gehostet und unterstehen diesen Richtlinien.